Dentin Sensitivity
Researchers evaluated randomized clinical trials involving nano-hydroxyapatite for dentin hypersensitivity and found nano-HAp treatments produced significant reductions in sensitivity overall.
Research study:
https://pubmed.ncbi.nlm.nih.gov/30611773/
Cavity Prevention
A systematic review of clinical studies found hydroxyapatite oral-care products showed evidence of caries-preventive effects, although the evidence base is smaller than the decades of research available for fluoride.
Research study:
https://pmc.ncbi.nlm.nih.gov/articles/PMC8641555/
Sensitivity 105-Person Randomized Trial
In a double-blind randomized trial involving 105 subjects, a nano-hydroxyapatite treatment significantly reduced cold-air and tactile sensitivity over two and four weeks.
Research study:
https://pubmed.ncbi.nlm.nih.gov/25019114/
Dentinal Tubule Occlusion Microscopic Evidence
Scanning-electron-microscope research has shown nano-hydroxyapatite accumulating on dentin and forming plugs within exposed dentinal tubules.
Research study:
https://pubmed.ncbi.nlm.nih.gov/29707852/